Question

Drug-A (t1/2° 1 5 hours; V-62 L; fu = 0.1; fe = 0.3) is administered twice a day for 2 weeks. Calculate the accumulation fact
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Answer #1

Here in the present scenario, the half-life of the drug is given as 15hrs

Thus we can calculate the

Ke= CL/VD = rate constant for elimination of the drug -> bigger clearance the faster elimination happens, the larger the VD the slower elimination happens = .693/(t1/2)

=0.693/15

=0.462/hr

Thus we can calculate the accumulation factor as 1/0.462

=2.16

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