Here in the present scenario, the half-life of the drug is given as 15hrs
Thus we can calculate the
Ke= CL/VD = rate constant for elimination of the drug -> bigger clearance the faster elimination happens, the larger the VD the slower elimination happens = .693/(t1/2)
=0.693/15
=0.462/hr
Thus we can calculate the accumulation factor as 1/0.462
=2.16
Drug-A (t1/2° 1 5 hours; V-62 L; fu = 0.1; fe = 0.3) is administered twice...
drug a (t1/2= 18 hours, v= 80l fe= 0.2 fu= 0.1) is administered as multiple 200 mg iv bolus every 12 hours. predict max concentration at steady state.
QUESTION 4 In one patient drug-A (t1/2° 10 hours; v-55L; fu-0.1 ; fe # 0.4; F-09) is administered as two 300 mg day. In another patient, the same drug is administered as one 200 mg tablet three time a day. The two dosing regimen have the same dosing rate. O True tablets once a e False
QUESTION 8 The administration of a 200 mg/day tablet of drug A (t1/2-12 hours; V 130L; fu 0.1; fe -0.3; F-0.9) results in ar average steady state concentration of 1 mg/L. What is the average amount (mg) in the body at steady state?
Typical pharmacokinetic parameters of DRUG-A are F-0.02; fex < 0.1; fu 0.3; V- 0.22 L/Kg Half-life 4 hours. Drug-A is administered as a continuous IV-Infusion to a patient taking another medication that is known to induce the hepatic-metabolism of Drug-A. Therefore, the time to reach steady state will: D Increase 0 Decrease O Show little difference
Calculate the hepatic clearance (Umin) of the drug 5-fluorouracil (fus 90%; fex < 196; V-18 L ; t1/2 = 1 1 min.
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F - 0.02; fe - 0.03; t 2-4 hours; Vd- 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL. a. Calculate the infusion rate necessary to maintain b. Calculate how long it will take to reach 90% of c. Calculate the loading dose. a steady state plasma concentration of 3 ug/mL steady state
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
A gas turbine receives air at temperature T1 = 827 °C and specific volume v, -0.1 m®/kg. Air exits the turbine at P2 = 3 bar and T2 = 450 °C. The volumetric flow rate of air at the inlet is 0.5 m/s. The power output on the shaft is 1900 kW. Determine: The pressure of air at the inlet (pa) in kPa [2 marks] b) The mass flow rate in kg/s [1 mark] c) Find the rate of heat...
6) It has been study. One een levels of treatment for the new drug will be used in the 2 study. One group will be administered the new phase of the drug once per day and a second group twice per day. You select two SRSs of 19 and 21 individuals who have been diagnosed as having high n diagnosed adrug twice per administered the new drug once per dayad cholest total cholesterol. Results are summarized in the table below....