Question

How are spiriva and servant different? How do they work? Can they be used togerher?

How are spiriva and servant different?

How do they work?

Can they be used togerher?

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Answer #1

1. Drug - Spiriva

# Classification:

Therapeutic: bronchodilators
Pharmacologic: anticholinergic

# Indications

Long-term maintenance treatment of bronchospasm due to COPD. Reducing exacerbations in patients with COPD.

# SideEffects

dry mouth, hypersensitivity reactions including angioedema.

# Implications

Do not confuse Spiriva (tiotropium) with Inspra (eplerenone).
• Advise patient to notify health care professional immediately if signs and symptoms of angioedema (swelling of the lips, tongue, or throat, itching, rash)

Drug - Serevent

# Classification:

long-acting beta2 adrenergic agonist
bronchodilator

# Action

stimulates beta2 - adrenergic receptors in lungs, results in relaxation of bronchiole smooth muscle

# Indication :

prevention of bronchospasm and maintenance associated with COPDs

# side effects:

headache

# Adverse effects

headache, pain, hypokalemia, hyperglycemia, nasal congestion, hypertension

# Contraindications

treatment of asthma without a concomitant long-term asthma control medication, such as an inhaled corticosteroid
status asthmatics or other acute episodes of asthma

2. Mechanism of Action of spiriva - Tiotropium is a muscarinic receptor antagonist, often referred to as an antimuscarinic or anticholinergic agent. Although it does not display selectivity for specific muscarinic receptors, on topical application it acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation, thus producing a bronchodilatory effect.

Mechanism of Action of serevent - serevent stimulates beta2 -adrenergic receptors in lungs , results in relaxation of bronchiole smooth muscle .

3. Yes, they can be given together as there is no drug interaction between them .

Compared to single-agent therapy, combination therapy of tiotropium plus salmeterol in COPD provided clinically meaningful improvements in airflow obstruction and dyspnea as well as a reduction in reliever medication.

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