Question

Which of the following statements regarding the relationship between
functional groups and their pharmacokinetic properties is/are CORRECT?
I. Carboxylic acids are more likely to be absorbed across biological
membranes when they are in the conjugate base form
II. Amines are more likely to be absorbed across biological membranes
when they are in the base form
III. Esters are metabolically unstable so are frequently not distributed to
the tissues intact
(a) I only
(b) II only
(c) III only
(d) II and III only
(e) All of I, II and III

Answer 1

Answer: II only

Amines are more likely to be absorbed across biological membranes when they are in base form.

(This is because the more soluble the lipids are ,they can easily absorbed across biological membranes.)