Question

You receive the following prescription to compound an ophthalmic solution: EPHEDRINE OPHTHALMIC SOLUTION FORMULA Ephedrine sulfate 0.25 g Sodium chloride QS Purified water ad. 30 ml Make an isotonic solution Ephedrine sulfate sodium chloride equivalent or E value = 0.23 How many milligrams of sodium chloride do you need to add to make an isotonic solution? II. You have a 23.4% solution of sodium chloride for injection. How many milliliters of this solution should you use to compound the prescription for ephedrine ophthalmic solution? III. What is the percentage concentration of ephedrine in the ephedrine ophthalmic solution?

Answer 1

(1) The amount of NaCl to make 30 me of an isotonic x = org x 38 100% LILLLLLL - 27 100 Eephedrine sulfate) given in question x = 0.27 0 Now, the amount / contribution) of ephedrine sulfate to the Nace equivalent (Eephedrine sulfate) Recent 0.259 x 0.23 = 0.0575g . The amount of Nade to add to make the solution isotonic by subtracting @ from 6. = 0.27g - 0515g

-A112 ) As given in question, there is 23.4 .4. solution of Nace for infection It means for every 1 me of infection 23.4 mg Nach will be there 11100 So, for 1 mg Nall required = 1 ml of injection is needed from calculation in part (I) of question, for 0.2125 mg Nal required = I x 0.2125 ml 23.4 -0.0427X0.2125 ml = 0.0090 me. is required.

(I) Percentage contentsation of ephedraie in ephedrine of thalmic solution is a 30 ml x x g = 0.25 g loomt x = 0 25x100 3 000 30% = 0.833 /