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A patient is given acetaminophen, diphenhydramine, and IV methylprednisolone before administering a dose of muromonab- CD3. W
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Muromonab CD3 is the murine monoclonal antibody against the CD3 glycoprotein located near to the T cell (thymus cell) receptor on the helper T cell.muromonab CD3 binds to CD3 antigen obstructs the binding of MHC 2 -antigen complext to the T cell receptor.Then the immune response is prevented by T cells and rapidly disappear from circulation leading to an immune blocked state,and it leads to produce allergic reactions due to less response of monoclonal antibody.

The frequent dose of muromonab CD3 is associated with cytokine release syndrome, includes the side effects like fever ,fatigue ,chills,wheezing and rigor.Occasionaly pulmonary edema are produced .So glucocorticoids like methylprednisolone, acetaminophen and diphenhydramine are given before the infusion to reduces the reactions.

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A patient is given acetaminophen, diphenhydramine, and IV methylprednisolone before administering a dose of muromonab- CD3....
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