Question

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1. (4 Pt) A new tissue engineering company would like to use autologous cell-seeded scaffolds as implants for the engineering of a few different joint tissues including U that the company invest in technologies to isolate chondrocytes from cartilage, ligament cells from ligament, and osteoblasts from bone so that cells can be grown individually in culture to increase their number before being seeded into scaffolds (1) What are the advantages and disadvantages of the consultant's recommendation? Advantages. 1) Cow mntanence crosto hot necessarily pis advantages: scale up is challenging. 215 meill sample size and reduce sensivetid (2) What reasons would you use to recommend, instead of the above approach, that the company invest in technology to grow stem cells for these applications?

Answer 1

1) (1) The advantages of consultant’s recommendation are as follows: Since autologous cells are appropriate for tissue engineering due to their high activity, patients can be benefitted with this special facility of receiving autologous cell seeded scaffolds as implants when required. Hence, there is further scope of collaborating with hospitals and doctors who can benefit with this technology.

The disadvantages of consultant’s recommendation are as follows: Investing in this complex technology holds risks, and does not guarantee positive results, in addition to the cost. Since, this involves autologous cells, meaning patients own cells, this involves patient consent which may be difficult to obtain. Donor-site morbidity due to infection and hematoma may be involved. Also, risks of rejection by the patient's immune system can also be present. If a patient is aged or has severely been diseased it can be difficult to grow the cells.

2)The company can be recommended to invest in this technology based on its scope and future perspective. This technology can benefit patients widely if developed on a large scale. In addition, autologous cell seeded scaffolds can be personalized according to patient need since it use patients own cells.

(3) Mesenchymal stem cells (MSCs) can be used in this technology. They should be used in undifferentiated form due to their expansion and multipotent potential. The sources of these cells can be musculoskeletal and cartilaginous.