Question

The first generation antipsychotics are drugs of choice because there is decreased risk of ANS interaction. True False

Answer 1

A) False. Because 1st generation antipsychotics( generally called typical antipsychotics) block the d2 receptors in 4 regions in the brain mainly nigrostriatal, mesocortical, mesolimbic and tuberoinfundibular. Due to blockage of d2 receptors in nigostriatal pathway causes tardive dyskinesia and parkinsonism( included in extrapyramidal symptoms) . 1. High potency typical antipsychotics- haloperidol and fluphenazine causes increased extrapyramidal symptoms and increased prolactin level.  

2. Low potency typical antipsychotics- like chloropromazine causes blockage of a-adrenergic receptors( causes orthostatic hypotension), cholinergic receptors( causes dry mouth, constipation) and histamine receptors ( causes sedation).  

Whereas 2nd generation antipsychotics like chlozapine, olanzapine causes sexual dysfunction, weight gain and decreased chance of extrapyramidal symptoms.

B)

Answer is e.

Because tropical local is not given because as wisdom teeth is extracted from the root it will not cease the pain sensation if tropical local is used. So as it supplied by the trigeminal nerve branches so regional nerve block and local infiltration is needed to numb the area. .