The Michael reaction is a conjugate addition reaction between a stable nucleophilic enolate ion (the donor)...
The Stork reaction is a condensation reaction between an enamine donor and an a,B-unsaturated carbonyl acceptor. The overall reaction consists of a three-step sequence of 1. formation of an enamine from a ketone, 2. Michael addition to an a,B-unsaturated carbonyl compound, and 3. hydrolysis of the enamine in dilute acid to regenerate the ketone. Consider the Stork reaction between acetophenone and 3-buten-2-one. 1 Draw the structure of the product of the enamine formed between acetophenone and dimethylamine. N - O...
Draw structural formulas for both resonance structures of the enolate ion obtained by treating the carbonyl compound below with base. In progress • You do not have to consider stereochemistry. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. • Separate resonance structures using the symbol from the drop-down menu. ChemDoodle Previous Next Draw a structural formula for the enol form of the carbonyl compound below. H3C CH3 Co @ 7...
Please answer the following question correctly and completely. (Please write neatly) (Please make sure to outline all of the steps of the synthesis to make the above product). Bonus compound was prepared via a Michael reaction: beta structures of an enolate ion Donor and Michael equivalent (Michael for the Michael addition carbonyl (Michael acceptor). Draw following compound donor), beta-unsaturated acceptor needed, and outline all of the steps of the synthesis. Mechanism is NOT needed. 8 points CN
1. draw the structure of the product of the enamine formed between cyclohexanone and morpholine 2. draw the structure of the Michael addition product 3. draw the structure of the final product This question has multiple parts. Work all the parts to get the most points. The Stork reaction is a condensation reaction between an enamine donor and an a,B-unsaturated carbonyl acceptor. The overall reaction consists of a three-step sequence of 1. formation of an enamine from a ketone, 2....
How might the following compound be prepared using a Michael reaction? Draw both the Michael donor and the Michael acceptor you would use. O NCH2 • You do not have to consider stereochemistry. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. • Separate multiple reactants using the + sign from the drop-down menu. ChemDoodle
O H2N-OH 2. нса a Electrophilic addition b-E2 Elimination d- Sy2 Nucleophilic substitution-Nucleophilic subs at carbonyl(acyl Xfer) e-Electrophilic aromatic substitution h -Conjugate (nucleophilic) addn SNI Nucleophilic substitution r-Carbonyl nucleophilic addn Identify the mechanism by which each of the reactions above proceeds from among the mechanisms listed. Use the letters a -i for your answers. 2. Submit Answor Retry Entire Group 9 more group attempts remaining
1. A Robinson annulation is a reaction that involves: (i) a Michael addition of an enolate onto an ,ß-unsaturated enone followed by (ii) an intramolecular aldol reaction. The molecule shown below (cyclohexenone X) can be made through two different Robinson annulation reactions. (A) Show the two different sets of starting materials (i.e. ketone 1 &a,p-unsaturated enone 1 and ketone 2 & a,B-unsaturated enone 2) for each Robinson annulation. Draw the reagents/reaction conditions. (B) Then pick one set and draw an...
6. Draw the structure of the Michael reaction product. Label the Michael donor and the Michael acceptor in each case and formulate the reaction. сH нс сом
This reaction is an example of conjugate addition of a nucleophile to an alpha, beta-unsaturated carbonyl. Draw the two resonance structures of the enolate anion intermediate for this reaction.
[References) [Review Toples] Draw the structure of the major organic product of the reaction. NH2 • You do not have to consider stereochemistry. • All carboxyl and amino groups should be drawn in the neutral form. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom • Separate multiple products using the + sign from the drop-down menu. @- / / OOO ChemDoodle Submit Answer Retry Entire Group 9 more group attempts remaining (Review...