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A case-control study was conducted to examine the association between a high fat diet and coronary...

A case-control study was conducted to examine the association between a high fat diet and coronary artery disease. Subjects with physician diagnosed heart disease and controls without heart disease are recruited and asked to complete questionnaires about their dietary habits in order to categorize them as having diets with high fat content or not. This situation is more likely to generate which type of bias:

a. non-differential misclassification

b. differential misclassification

c. selection bias

d. none of the above

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Answer #1

In this situation, a self evaluation questionnaire is used to determine dietary fat content. The calculation of dietary fat content from a questionnaire is not very accurate and may cause misclassification. However the probability of this misclassification is equal in both the heart diseased subjects as well as the control subjects.

Thus this study will most likely have a non-differential misclassification.

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