biochem question 9. Determine the net charge of the predominant form of Asp at (a) pH...

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biochem question

Answer 1

Answer #1

Aspartic acid: pKa1: 1.88; pKa2: 9.60; pKa 3: 3.65(side chain)

pI: 2.77. (have carboxyl, amino and side chain groups

a) At pH 1 charge will be +1 because aspartate remain protonated at carboxyl, amino ends and also at side chain.

b) At pH 3.0 charge will be neutral because aspartate gets Deprotonated at carboxyl, but remain protonated at amino end and at side chain.

c) At pH 6.0 charge will be -1 because aspartate gets Deprotonated at carboxyl and at side chain but remains protonated at amino end.

d) At pH 11.0 charge will be -2 because aspartate gets Deprotonated at carboxyl, amino end and also at side chain.

Answer 2

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