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13. What would be the overall charge of a peptide of the following sequence at pH=5...
A peptide has the sequence Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly a)name the peptide b)what is the net charge of the...
A peptide has the sequence Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly a)name the peptide b)what is the net charge of the molecule at Ph 3,8,12 c) Estimate pl
6. A peptide has the sequence Cys-His-Phe-Glu-Ala-Arg a. Write the single letter sequence of the peptide...
6. A peptide has the sequence Cys-His-Phe-Glu-Ala-Arg a. Write the single letter sequence of the peptide b. Calculate the percentage and indicate the charge of the predominant peptide species at pH 6.5. Use the following pKa values: pKa Cys = 8.3, pKa N-terminus = 10.8, pKa His =6.0, pKa Glu = 4.3, pKa Arg = 12.5, pKa C-terminus =2.0 c. What is the charge of the peptide at pH 4.3? d. Draw the chemical structure of the predominant peptide species...
What is the approximate net charge of the following pentapeptide at pH 10? Arg-Gln-Cys-His-Ala What is...
What is the approximate net charge of the following pentapeptide at pH 10? Arg-Gln-Cys-His-Ala What is the Isoelectric point (pI) of the peptide given above? Use the pKa values given here when needed: Side group/ amino acid pKa Asp 3.9 Glu 4.1 HIs 6.0 Cys 8.4 Tyr 10.5 Lys 10.5 Arg 12.5 C-term 3.5 N-term 9.0
Please explain. 8. What will be the overall charge of the following peptide in the following...
Please explain.
8. What will be the overall charge of the following peptide in the following pH values? (10 points) Arg Glu Glu Lys Asn Trp Met Tyr Arg Leu Lys OH Overall 7 14 4
The isoelectric point (pI) of a peptide is the pH at which the peptide does not...
The isoelectric point (pI) of a peptide is the pH at which the
peptide does not migrate in an electric field. Since the peptide is
zwitterionic, there are the same number of positive charges as
negative charges on the peptide population. The pI can be estimated
fairly accurately (within 0.1 or 0.2 pH units) from the pK values
of all the proton dissociable groups in the peptide. Using pK
values from the table at the right, estimate the pI value...
true or false. at physiological PH, nearly all amino acids have overall positive charge True False...
true or false. at physiological PH, nearly all amino acids
have overall positive charge
True False 1) At physiological pH, nearly all amino acids have an overall positive charge. 2) The dipeptide abbreviated as Gly-Lys is the same as the dipeptide abbreviated as Lys-Gly. tide 3) The peptide sequence Gly-Gly-Gly gives the primary structure of a tripeptide. 4) The u-helix is a secondary structure. 5) The triple helix of collagen is a tertiary structure.
Which one is the major product of the following reaction sequence? NH 1. excess CHI 2....
Which one is the major product of the following reaction sequence? NH 1. excess CHI 2. Ag,0,H,O heat A decapeptide that is part of an insulin-like peptide has the molecular formula: Gly, Asp(2), Arg, Ser, Phe, Cys(2), Val(2). After partial hydrolysis, the fragments are: Val-Asp-Ser Asp-Phe-Arg-Gly Ser-Cys-Cys Gly-Val-Val What is the sequence? Gly-Val-Val-Asp-Ser-Cys-Cys-Asp-Phe-Arg Asp-Phe-Arg-Gly-Val-Val-Asp-Ser-Cys-Cys Asp-Cys-Cys Arg-Gly-Val-Val-Phe-Arg-Gly Val-Asp-Ser-Cys-Cys-Asp-Phe-Arg-Gly-Val Which aldehyde or ketone AND amine reactants are needed to complete the following reaction? Amine N.BH CN dil H,09 NH(CH3 NH(CH3 NICH) (CH2)...
Can someone explain how these work? 4. For a solution of Cys (C), at what pH...
Can someone explain how these work?
4. For a solution of Cys (C), at what pH would the net charge be closest to 1? a) 10.7 b) 8.4 c) (1.9-8.4)/2 = 5.5 d) (10.7 + 8.4)/2 = 9.55 5. For a solution of Tyr (Y), what percentage of the side chain R group's OH would be deprotonated at pH = 10.5? a) 0% b) 25% c) 50% d) 100% 6. For the peptide His -Asp-Gln-Glu-Ala- Lys (HDQEAK), what would be...
-2. Which of the following tripeptides would carry a net charge of-1 at pH 7? Markallthatapply....
-2. Which of the following tripeptides would carry a net charge of-1 at pH 7? Markallthatapply. (3 pts.) A. Asp-Ala-Arg C. Lys-Gly-Asn D. Glu-Lys-Asp E. Leu-Asp-Glu F. Arg-lleu-Cys B. Met-Pro-Glu The Kd for a dimeric protein complex is 2.2 μM. (3 pts.) Mark all that are true about this dimeric protein complex. A. 3. At equilibrium, the concentration of the individual subunits is very, very low. B. If this is a homodimer, it can be called an αβ dimer. C....
Can anyone confirm if these are correct? List and draw the structure(s) the amino acid(s) in...
Can anyone confirm if these are correct?
List and draw the structure(s) the amino acid(s) in which would have a-1 net charge at pH? List the amino acid(s) in which would have a + 1 net charge at pH 7? Draw the structure- of the peptide Arg-Asp-His-Ser-Gly at pH 7. List the N-terminus and C-terminus. Make sure the amide bonds are 'trans'. Give the products of a trypsin digestion of the peptide: His-phe-lys-val-asp-asp-arg-val Draw the full structure of the predominant...
6. A peptide has the sequence Cys-His-Phe-Glu-Ala-Arg a. Write the single letter sequence of the peptide b. Calculate the percentage and indicate the charge of the predominant peptide species at pH 6.5. Use the following pKa values: pKa Cys = 8.3, pKa N-terminus = 10.8, pKa His =6.0, pKa Glu = 4.3, pKa Arg = 12.5, pKa C-terminus =2.0 c. What is the charge of the peptide at pH 4.3? d. Draw the chemical structure of the predominant peptide species...
Please explain.
8. What will be the overall charge of the following peptide in the following pH values? (10 points) Arg Glu Glu Lys Asn Trp Met Tyr Arg Leu Lys OH Overall 7 14 4
The isoelectric point (pI) of a peptide is the pH at which the
peptide does not migrate in an electric field. Since the peptide is
zwitterionic, there are the same number of positive charges as
negative charges on the peptide population. The pI can be estimated
fairly accurately (within 0.1 or 0.2 pH units) from the pK values
of all the proton dissociable groups in the peptide. Using pK
values from the table at the right, estimate the pI value...
true or false. at physiological PH, nearly all amino acids
have overall positive charge
True False 1) At physiological pH, nearly all amino acids have an overall positive charge. 2) The dipeptide abbreviated as Gly-Lys is the same as the dipeptide abbreviated as Lys-Gly. tide 3) The peptide sequence Gly-Gly-Gly gives the primary structure of a tripeptide. 4) The u-helix is a secondary structure. 5) The triple helix of collagen is a tertiary structure.
Which one is the major product of the following reaction sequence? NH 1. excess CHI 2. Ag,0,H,O heat A decapeptide that is part of an insulin-like peptide has the molecular formula: Gly, Asp(2), Arg, Ser, Phe, Cys(2), Val(2). After partial hydrolysis, the fragments are: Val-Asp-Ser Asp-Phe-Arg-Gly Ser-Cys-Cys Gly-Val-Val What is the sequence? Gly-Val-Val-Asp-Ser-Cys-Cys-Asp-Phe-Arg Asp-Phe-Arg-Gly-Val-Val-Asp-Ser-Cys-Cys Asp-Cys-Cys Arg-Gly-Val-Val-Phe-Arg-Gly Val-Asp-Ser-Cys-Cys-Asp-Phe-Arg-Gly-Val Which aldehyde or ketone AND amine reactants are needed to complete the following reaction? Amine N.BH CN dil H,09 NH(CH3 NH(CH3 NICH) (CH2)...
Can someone explain how these work?
4. For a solution of Cys (C), at what pH would the net charge be closest to 1? a) 10.7 b) 8.4 c) (1.9-8.4)/2 = 5.5 d) (10.7 + 8.4)/2 = 9.55 5. For a solution of Tyr (Y), what percentage of the side chain R group's OH would be deprotonated at pH = 10.5? a) 0% b) 25% c) 50% d) 100% 6. For the peptide His -Asp-Gln-Glu-Ala- Lys (HDQEAK), what would be...
-2. Which of the following tripeptides would carry a net charge of-1 at pH 7? Markallthatapply. (3 pts.) A. Asp-Ala-Arg C. Lys-Gly-Asn D. Glu-Lys-Asp E. Leu-Asp-Glu F. Arg-lleu-Cys B. Met-Pro-Glu The Kd for a dimeric protein complex is 2.2 μM. (3 pts.) Mark all that are true about this dimeric protein complex. A. 3. At equilibrium, the concentration of the individual subunits is very, very low. B. If this is a homodimer, it can be called an αβ dimer. C....
Can anyone confirm if these are correct?
List and draw the structure(s) the amino acid(s) in which would have a-1 net charge at pH? List the amino acid(s) in which would have a + 1 net charge at pH 7? Draw the structure- of the peptide Arg-Asp-His-Ser-Gly at pH 7. List the N-terminus and C-terminus. Make sure the amide bonds are 'trans'. Give the products of a trypsin digestion of the peptide: His-phe-lys-val-asp-asp-arg-val Draw the full structure of the predominant...
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