Question

1. You are asked to analyze the following two solutions:

Solution 1 – acetaminophen, ibuprofen, and aspirin

Solution 2 – methyl t-butyl ether, isooctane and n-butanol (gasoline additives)

Explain which chromatographic technique (GC or HPLC) you would use to separate each of these mixtures and why that technique would be useful for that separation. Indicate columns and detectors when appropriate.  

Answer 1

E DAs per the given Solution-1 = data : page-1 OOH owSYAYIPIAS YUZASSASIrrer Compounds Aspirin compound-A CYDU YEYOYOYIurin 애 acetaminophen 얘 J-pusodnos T ibuprofen

page-2 The given 3 compounds can be seperated easidy by HPLC. since they all have different polarity A/Nonpoas) > B(lesspoleo) >c (polar) In this seperation the compo and El will comes first from APLC then after B and last A will obtain. 3 dlution-2: Amethyl-t-butyl Ether B Iso octane OH ©n-butanol

page-3 The 3 compounds given are seperated easily by HPLC technique, on the basis of their polarity. ® non-polar > Ô less polar > OlPoland Here the compound c' come first theretter ' À and finally the compound 'B' will obtain - X - please vote positively, will you sartesty with this Explenation. WawiaWANAUAWAT