Question

Explain in detail how the human body destroys the wear UHMWPE particles/debris in a total joint replacemen

Answer 1

The Complication involved in wearing UHMWPE particle in total joint replacement :-

In this present reality where expanding joint arthroplasties are being performed on progressively more youthful patients, osteolysis as the main source of disappointment after absolute joint arthroplasty (TJA) has increased impressive consideration. Ultra-high sub-atomic weight polyethylene wear-initiated osteolysis is the procedure by which prosthetic precisely discharged from the outside of prosthetic joints instigates an invulnerable reaction that favors bone catabolism, bringing about slackening of prostheses with eventual failure or fracture. The invulnerable reaction started is inborn in that it is vague and self- engendering, with monocytic cells and osteoclasts being the principle effectors. Periprosthetic osteolysis is the process by which biological or mechanical forces initiate a local immune response in periprosthetic tissue that eventually results in implant loosening and failure. Although this could be due to a number of factors such as infection, wear-induced osteolysis is induced by wear particles mechanically released at the articulating surface of prostheses over time. UHMWPE particles induce inflammation and stimulate macrophages by a variety of mechanisms. One such mechanism occurs through Toll-like receptor (TLR) activity. TLRs are expressed in many inflammatory cells, especially those of monocytic lineage, and their stimulation promotes phagocytosis and initiates an innate immune response mediated through NF-KB activation