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Q1-10pts) a) What is the general principle that describes how enzymes work as catalysts? b) How does an enzyme/catalyst affect the free energy difference between the initial and the final states of the reaction? c) A chemical reaction (A -> B) has a free energy difference AGAB-10 kcal/mol. However, the reaction is slow and in the absence of an enzyme the activation free energy barrier is 12 kcal/mol. If an enzyme increases the reaction rate 1000-fold at 300 K, what is the catalyzed activation free energy barrier?

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Answer #1

(a)- Enzymes are proteins functioning as catalysts. Like other catalysts , enzymes are characterized by two fundamental properties. First, they increases the rate of chemical reactions without themselves being consumed or permanently altered by the rwaction. Second, they increase reaction rates without altering the chemical equilibrium between the reactants and products .

(b) As the stated above the enzyme or catalyst does not disturb the states or reactant or product, so the free energy difference will remain same after the use of catalyst or enzyme.

An uncatalyzed reaction requires a higher activation energy than does a catalyzed reaction There is no differ- u Reactants en

(c) os R x%) Rake 는 k CA) presence erRYme, odivation on eMTeout be chomged &ade noco-fold ca looo K uction(2 1000 = e Mo Mol

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