Question

I answered E but I cannot figure out part F?

Using your value from the previous question, determine how many H bonds or dipole interactions would be required to achieve a rate enhancement of 10^6.
Part E A rate enhancement of 100 requires that the enzyme bind its transition state complex with higher affinity than its substrate. Using the Arrhenius equation, shown before this part, find AAGEat for a rate enhancement of 106 at 298 K. Express AAGEat in kJ/mol to three significant figures. 34.2 kJ/mol Submit Previous Answers ✓ Correct AAG is the difference in free energy of the transition state between the uncatalyzed and catalyzed reaction. Since the catalyzed reaction has a lower activation energy at the transition state, it is expected to also have a more favorable AG value.

Answer 1

# from part E 1. We got DD Gear = 34.2kJ/mol Nocy given, for Rate enhancement Energy of 106. of Hydrogen bonds = 10 to 40. i total number of H- bonds will be. ůn,(344 40 10 10 = 0.855 to 3.42 Irand off 2 0.86 to 3.42 Answer) loshi + Sheat + 0 to A D G cat] =12 - nuen, Energy of dipole -dipole interactional = 5 to 25 2) Number of dipole -dipole Interactions a sheet. OG I to CC 15 2393 to 3452

= 1.368 to 6.84 Drund aff =) 1.37 to 6.48 ( Answer). #sm. In order to get number of bonds (H-bond or Dipule -Dipole) we need to devide ao Gaatat (which is an energy term) by Energy per bond [ Devide both energy terms] sogt (kg/moll bonds = Energy per bima (kJ/mol Total number of