What is the pI of glutamate? pK1= 2.2 pK2=3.5 pKr=8.5 Rule: pH > pKa deprotonated, pH...

Question

Question

What is the pI of glutamate? pK1= 2.2 pK2=3.5 pKr=8.5

Rule: pH > pKa deprotonated, pH < pKa protonated

Answer 1

Answer #1

pI of glutamate

pI is the pH at which net charge on molecule is zero

so,

the pI for glutamate = 1/2(2.2 + 3.5)

= 2.85

at this pH, the side chain carboxylic acid would remain in protonated neutral form, so the net charge on molecule is zero.

Answer 2

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