Question

Many different NOD-like receptors, including several with pyrin domains and several with HIN domains, can function to trigger inflammasome assembly leading to the activation of caspase-1. The reason for many different sensors in this innate response system is that:

a.Each NOD-like receptor binds to a different adapter protein and triggers a different form of the inflammasome

b.Each NOD-like receptor is expressed in a different set of phagocytic cells, depending on its tissue location

c.Each NOD-like receptor recognizes different PAMPs and is activated by different pathogens

d.Each NOD-like receptor performs a different step in the multi-step cascade leading to inflammasome activation

Answer 1

NOD like receptors are pathogen recognition receptors (PRRs) that recognize conserved microbial structures often referred to pathogen-associated molecular patterns (PAMPs).Existence of multiple NOD like receptors ensures detection of diverse pathogens.There option c is the correct answer.

Option a is wrong because many NOD like receptors bind to same adapter protein.Option b is wrong because many NOD like receptors are expressed in common immune and epithelial cells.Option d is wrong because many NOD like receptors activate the same step for inflammosome activation.