Q4: Tau proteins are abundant in neurons, and help to stabilize cellular microtubules. When denatured and...
Q4: Tau proteins are abundant in neurons, and help to stabilize cellular microtubules. When denatured and unfolded, they can assemble to form plaques that are thought to be important in the pathology of Alzheimer's disease. For this system: (a) Calculate AG& if we assume that, at equilibrium, 10% of Tau proteins are found in the unfolded state. (b) Calculate the enthalpy of unfolding given that AS d = 98 v (c) If we add a drug that binds to the Tau protein and increases its AG by +6 kcal/mol, what is the new equilibrium constant? Which will now be more favored, the folded or unfolded state?