Robinson annual synthesis.
1. Draw the major product(s) from the following Robinson Annulation reactions: Linda 2. Provide the starting...
1. Draw the major product(s) from the following Robinson Annulation reactions: worden. Bukan HCX HiC CHO + Eto Na EIOH CH. HTC Eto Na Etон CH3 u ovo malom + HC CH, Eto Nat EIOH CH3
1. (28 pts. total) Draw the major organic product of the following reactions or provide reagents for the transformation. Assume an aqueous workup in each case. Indicate the stereochemistry where necessary a) 7 pts OH PCC b) 7 pts. Lindlar catalyst c) 7 pts. Predict the starting materials that were used to form the following molecule via Robinson annulation. Robinsca annulation d) 7 pts. Predict the starting materials that were used to form the following molecule via reaction followed by...
Draw Michael addition product and the final Robinson annulation product. These are starting materials, Н. Н. о о о
Problem #1 Identify the major product(s) from the following reactions: OET Eto Na ELOH OEt 1. Br2, HOẶC 2. Pyridine 3. (CH3CH2CH2)2Culi
Provide the major product(s) for the following Provide the major product(s) for the following reactions. Be sure to note stereochemistry and racemic mixtures. NaOH, H29 2 100 °Ç ? NaOH, H2O H 0°C H W H CCl3 OC (provide product of both steps) H a. Hn b. CHEM 370 W13 Homework Page 1 of 2 giorel Noot Hoi solu NOEL IN DER NaOH, H2O 100 °C Hv NaOET, H OEt EtOH 8. Eto- i. LDA, -78°C NaO Me MeOH Оме...
1. A Robinson annulation is a reaction that involves: (i) a Michael addition of an enolate onto an ,ß-unsaturated enone followed by (ii) an intramolecular aldol reaction. The molecule shown below (cyclohexenone X) can be made through two different Robinson annulation reactions. (A) Show the two different sets of starting materials (i.e. ketone 1 &a,p-unsaturated enone 1 and ketone 2 & a,B-unsaturated enone 2) for each Robinson annulation. Draw the reagents/reaction conditions. (B) Then pick one set and draw an...
Provide a chemical structure(s) for the major product in the structure(s) for the major product in the following reactions. If a chiral center is produced please give the correct stereochemical assignment at the chiral center (Q. 14,3 pts ea.). HBT 1. Peroxides HBr HO NaOH HO Eto Nat Br EtOH 5. Show how to convert cyclohexane into racemic 3-bromocyclohexene. Provide all reagents and structures of molecules synthesized along the way. (8 pts).
please complete number 1 and 2 COMPLETELY The Robinson annulation is a classic example of what could be considered a paired reaction - that is a reaction that is made up of a sequence of two simpler reactions. In the case of the Robinson annulation, it is a Michael Addition followed by an intramolecular aldol. For the following Robinson annulation, go through the mechanism of the initial Michael addition and then look at how many different intramolecular aldol reactions could...
1. The Robinson annulation is a classic example of what could be considered a paired reaction- that is a reaction that is made up of a sequence of two simpler reactions. In the case of the Robinson annulation, it is a Michael Addition followed by an intramolecular aldol. For the following Robinson annulation, go through the mechanism of the initial Michael addition and then look at how many different intramolecular aldol reactions could happen. Analyze each one in terms of...
1. For each of the following reactions, provide the structure of the major organic product(s). Show all the relevent stereochemistry clearly. who CH2OH reflux CH2CH3 Na SET Br DMSO, 20 °C I- A to CH2CH3 CH3 H- EtOH OTS 20 °C Me NaNH2 NH2 DMSO dilute solution of substrate 2. Complete each of the following reaction by providing reagents and conditions (solvent. temperature, concentration, etc.) so that the product shown will be the major one. Note: for c), two steps...