Question

Why is my IV green? Solubility is a property of mixtures with far reaching effects in biology, medicine, and other technical fields. For this discussion board, research the causes and effects of IV (intravenous drug incompatibility and answer the following questions. Be sure to reference the solubility rules discussed in Chapter 9 of the book during your research and while answering the questions. Back up your responses with your sources. Once you have completed your post, respond to one additional student's answer to question 4 and discuss similarities and differences between your professions and risks. This Assignment is worth 50 points. 1. What are some of the causes of IV drug incompatibility and what can their results be? 2. Nitrates, sulfates, chlorides, and phosphates are common ions used in medicine. Based on the solubility rules, would you expect to have any drug incompatibilities from mixing these ions with any metal ions relevant to biology or medicine? Why or why not? 3. Do you think the principles behind IV drug incompatibility can also be applied to other applications or modes of drug delivery? If so, what kind of applications could it be applied to? If not, why not? 4. How does solubility and/or drug incompatibility relate to your intended profession? Are there particular problems that could arise if you didn't check?

Answer 1

Answer:

1):

• Incompatibilities of drugs in standard IV therapy can occur between:​

​$\rightarrow$ drug and inappropriate solutions as if dilutents.

$\rightarrow$ mixing of two drugs I.e. drug drug incompatibility

$\rightarrow$ drug and drug container reaction.

$\rightarrow$drug and adjuvants.

• The unintended presence of precipitation and toxic products can cause various negative consequences for the patient.

​$\rightarrow$ damage from toxic products.

$\rightarrow$tissue irritation due to major ph Changes

$\rightarrow$ emboli formation due to crystallisation of drug.

$\rightarrow$therapeutic failure.

2):

• Nitrates and chlorides are highly soluble and have few precipitates among metal salts.
• However, sulfates form a low solubility salt with calcium, common in many medications.
• And phosphate also forms low solubility salts with calcium and magnesium that are in medications.

3):

$\rightarrow$The route used to give a drug depends on three main factors:

• the part of the body being treated
• the way the drug works within the body
• the formula of the drug

$\rightarrow$For instance, some drugs are destroyed by stomach acid if they’re taken by mouth.

• So, they may have to be given by injection instead.

$\rightarrow$To avoid iv drug incompatibility- avoid mixing of inappropriate drugs

• monitoring
• use of any other route.

4):

• Solubility and drug incompatibility both are important while producing new drugs cause they affect drug theraupatic levels
• SOLUBILITY it is property of substance to get dissolve in liquid I. e. Solvent
• More soluble form can achieve more theraupatic level
• At cellular level drug has to be delivered in aqueous form for better absorption
• DRUG INCOMPATIBILITY it is a process In Which interaction of two or more substances affect chemical physical and theraupatic level

$\rightarrow$Hence three types of incompatibility

$\rightarrow$1.physical

$\rightarrow$2.chemical

$\rightarrow$3.theraupatic

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