Question

November 20, S8. Parkin is an 3 uhiquitin ligase that is mutased in familial Parkinson's disease. Which protein is a arget of parkin-mediated ubiquitination? A. alpha synuclein dopamine D. prosine hydroxylase E. huntingtin 89. The following are all toxin models of Parkinson's except A. MPTP B. 6-hydroxydopamine C paraquat D. rotenone E. 3-nitropropionic ackd 90 la the basal ganglia, what is the effect of dopaminergic innervation to the striatal medium spiny GABAergic neurons? A. inhibition B. activation C, there is no dopaminergic innervation of medium spiny neurons D, none of the above 91. In the basa spiny GABAergie neurons? l ganglia, what is the effect of muscarinic cholinergic innervation to the striatal medium A. inhibition B. activation C. there is no muscarinic cholinergic innervation of medium spiny neurons D. none of the above A. selegiline B. entacapone C. benztropine D, amantadine E. carbidopa 93. Huntington's disease is also known as a poly 2 or polyglutamine expansion disease. 94. ALS is also known as- 95. Mutations in this gene account for almost 20% of all familial cases of ALS. disease 96. Riluzole is the only drug approved for ALS. Its mechanism of action is anti-

Answer 1

ANS 88) Protein that is a target of parkin mediated ubiquitiations is :

C) dopamine

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ANS 89) E) 3- nitropropionic acid

Toxins models of Parkinson's are  6-hydroxydopamine, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine that is MPTP, rotenone, and paraquat.

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ANS 90) Effect of dopaminergic innervention to the striatal medium spiny GABAergic neurons:

B) activation

because it helps in modulation and activation of striatal interneurons.

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ANS 91) Effect of muscarinic cholingergic innervention to the striaral medium siny of GABAergic neurons:

C) there is no muscarinic cholinergic intervention of medium spiny neurons

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ANS 92) The catechol-o-methyltransferase inhibitor for treatment of parkinson's disease:

E) carbidopa

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ANS 93) Huntington's disease is also known as poly Q or polyglutamine expansion disease

because it arises due to toxicity of polyglutamine with N terminus of huntingtin protein

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ANS 94) ALS is also known as Amyotrophic lateral sclerosis

in this disease a person's neurons become non functional

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ANS 95) Mutations account for almost 20 percent of all familial cases of ALS

False, mutations account for 50 percent chances of development of ALS in a family

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ANS 96) Riluzole is the only drug approved for ALS. Its mechanism of action is anti glutamate

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ANS 97) Generalized seizures are:

C and D that is grand mal and petit mal

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ANS 98) YES, an electroencephalogram EEG can be used to diagnose a seizure.

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ANS 99) Rhytmic burst firing of nuclear reticularis thalmic neurons can be inhibited by ethosuximide drug with ion channel of:

D) T-type Ca ²⁺ channels

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ANS 100) Drug that i used for Mixed Na+ and Ca 2+ channel blocker also inceases free GABA : LEVETIRACETAM

ANS 101) Drug that i used for Locks Na+ channel in their inactive site: PHENYTOIN

ANS 102) Drug that i used for Decreases GABA reputake by inhibiting GAT-1: GABAPENTIN

ANS 103) Drug that i used for Thought to promote the non vesicular release of GABA:  VIGABINE

ANS 104) Drug that i used for A cyclic GABA derivative with an unknown mechanism action: VALPROIC ACID

ANS 105) Drug that i used for Decreases GABA breakdown by inhibiting GABA transaminase: TIGABINE