Question

The mechanism involves donation of a hydride from ethanol to reduce the diazonium salt as shown here. After the first reaction (Step 1), each subsequent reaction uses the product of the previous step. The amounts of all reagents used, including solvents, must be sealed according to the amount of product obtained in the previous step (after saving at least 25 mg of the product for characterization and spectral analysis in each step). Prelab Assignment Calculate the theoretical mass of 1-bromo-3-chloro-5-iodobenzcnc starting from 5 g of aniline. Suppose that a 75% yield is obtained in each step of the reaction. What mass of 1-bromo-3-chloro-5-iodobcnzenc would be obtained? Write a flow scheme for each reaction and workup procedure in the synthesis. Write detailed reaction mechanisms for the following reactions: reaction of aniline with acetic anhydride. reaction of acetanilide with bromine. reaction of 4-bromoacctanilide with chlorine. hydrolysis of 4-bromo-2-chloroacetanihdc with HCl and ethanol. reaction of 4-bromo-2-chloroaniline with ICl. preparation of the diazonium salt. Experimental Procedure Part A: Synthesis of Acetanilide from Aniline Wear eye protection at all limes in the laboratory. HCl is corrosive and toxic. Use gloves when handling this reagent.

Answer 1

+1249 23 0,0538 mol. 0.0538 me -. Acceding 'to