6: An NMR analysis of the drug Fluvastatin indicates that it loses rotational and translational degrees...
6: An NMR analysis of the drug Fluvastatin indicates that it loses rotational and translational degrees of freedom upon binding to HMG-CoA reductase. Additionally, many internal bond rotations are restricted. Yet, an isothermal titration calorimetry experiment indicates that the binding reaction has favorable change in entropy. What is the likely source of the favorable binding entropy change?