Question

Exercise 1: Comparison of NSAIDs

Data Table 1. Comparison of Common NSAIDs.

Generic name	Commercial brand name(s)	Prescription only	Typical uses	Enzymes inhibited	Source(s)
Meloxicam	Mobic	x	Reduce pain and swelling associated with osteoarthritis and rheumatoid arthritis	COX-1 & COX 2	Indicate your resources here
Aspirin
Naproxen
Ibuprofen
Celecoxib
Diclofenac

Questions

Define the acronym NSAID. Why are NSAIDs valuable to medicine?

What property of aspirin makes it unique among the NSAIDs?

Define the roles of the cyclooxygenase enzyme and prostaglandins in the body. What types of stimuli prompt the production of the two forms of the cyclooxygenase enzyme?

How do NSAIDS work to block pain?

In Data Table 1, which NSAIDs are selective for COX-2?

According to Data Table 1, what are some ailments that all of the NSAIDs treat?

Identify four general properties that make an NSAID unique as compared to the NSAID aspirin. List specific properties that make aspirin, naproxen, and ibuprofen unique from one another.  

Answer 1

ans 1. NSAID is the acronym for non steroidal anti inflammatory drugs. These drugs are valuable in medicine as they provide relief against pain and fever (analgesic and antipyretic effect) as well as they have anti-inflammatory properties when administered at a higher dose than usual.

ans 2. Aspirin is unique because of its ability to control heart attacks. It can do so by preventing blood clot formation and thus preventing heart attacks.

ans 3. Prostaglandins produce an inflammatory effect in the body in response to any injury or infection in the body.,The cyclooxygenase enzyme is responsible for the production of prostaglandins and is secreted when there is any injury or infection detected in the body.

ans 4. The NSAID's help in blocking pain because they are able to inhibit the enzymes cyclooxygenase 1 and 2 therefore no prostaglandins are produced and no inflammatory response is then produced in the body.