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Mutations in the CFTR gene result in cystic fibrosis in humans, a condition in which abnormal...

Mutations in the CFTR gene result in cystic fibrosMutations in the CFTR gene result in cystic fibrosis in humans, a condition in which abnormal secretions are present in the lungs, pancreas, and sweat glands. In the effort to positionally clone the CFTR gene, the gene was mapped to a region of 500 kb on chromosome 7 containing three candidate genes. Using your knowledge of the disease symptoms, how would you distinguish between the candidate genes to decide which is most likely to encode the CFTR gene?

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Answer #1

A.

CFTR gene is expressed in

i. sectreted by epithelial cell

ii. acts as secretory protein

iii. acts as transmembrane protein

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