A simple noncompetitive inhibitor of acetylcholinesterase binds to the enzyme to affect Vmax only; it does...
A simple noncompetitive inhibitor of acetylcholinesterase binds to the enzyme to affect Vmax only; it does not affect KM.
Part A For an inhibition constant of KI=2.9×10?4M, what concentration of inhibitor is needed to give a 90% inhibition of the enzyme? Express your answer using two significant figures and include the appropriate units. [I] =
Homework Answers
Ans. # Given, Vmax is decreased but Km remains unaffected. It is the characteristic of a non-competitive inhibition. Therefore, the given inhibitor is a non-competitive inhibitor.
# On a 100 unit scale-
Vmax = 100
Vmax,app = Vmax – 90% of Vmax = 100 – 90 % of 100 = 10
![Mixed Inhibition Given- 100 Vmax Vmax,app= 10 KT0.00029 M Vmax Vmax,app Ki. α -1 100 a- -10 10 [1]-KI, (α-1) [1]= Now, 0.00](http://img.homeworklib.com/questions/34a199a0-ce30-11ea-a52a-91112f0d5556.png?x-oss-process=image/resize,w_560)
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A simple noncompetitive inhibitor of acetylcholinesterase binds
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