Homework Answers
1.
In the first step iodine attack from top face and form iodonium
cation in above face.
2. In the second step, hydroxyl base attacks from below and open three-membered iodonium ring.
3. in this step hydroxyl base took proton from the alcohol group and make a negative charge on the oxygen atom.
4. last step negative charge on oxygen atom attack iodine bearing carbon atom and removed iodine and form epoxide as our desired product.
Add Answer to:
3. In Corey's synthesis of PGF2, a key step is the stereoselective epoxidation of the Compound...
Please Note: In cases when an instruction is given for a certain number of C atoms...
Please Note: In cases when an instruction is given for a certain number of C atoms in your reagents that you may use, (e.g., any reagents of 3 or fewer C's), they are meant only for those reagents whose C atoms are passed to the target molecules. Also, a 20's reagent would mean two consecutive C's. For example, CH3CO2CH2CH3 would be regarded as a 2C's reagent. 3. In Corey's synthesis of PGF2, a key step is the stereoselective epoxidation of...
Question 3 (continued) (6) The drug phenaglycodol can be synthesized via a 3-step synthesis shown in...
Question 3 (continued) (6) The drug phenaglycodol can be synthesized via a 3-step synthesis shown in Scheme 1 below. Study the synthesis and answer the following questions. HO OEt NaCNag) H2O* in EtOH A Step 1 Step 2 CI CI Compound 3 2 mol B Step 3 followed by H30* HO OH CI phenaglycodol Scheme 1 (1) Identify the electrophile and nucleophile present in Step 1 (2 marks) (1) Draw the structure of Compound A (2 marks) (111) Identify reagent...
help? 3. (6 points) The synthesis of cosalane, a new anti-HIV agent, has the following step:...
help?
3. (6 points) The synthesis of cosalane, a new anti-HIV agent, has the following step: COOH COOH COOH HO ÇOOH сон H2SO4 HO HO OH CI 2 equiv 1 equiv Final Product Intermediate X (a) Draw an arrow-pushing mechanism for the formation of intermediate X. Show clearly how chemists rationalize the regioselectivity actually observed in the reaction. Resonance structures may help your argument. (b) Intermediate X is rapidly transformed under the reaction conditions to the final product. What is...
10. Select the compound that can not be made using the malonic ester synthesis: O O...
10. Select the compound that can not be made using the malonic ester synthesis: O O OH MeO Оме OH Ph OH A. B. Ph C. D. 11. In general both the malonic ester and acetoacetate synthesis require the addition of dilute acid in order to generate the final product. Why? A. the alkoxy cation needs to be eliminated C. the ionized cation partitions to the aqueous layer B. the stabilized enolate adds a proton in the separatory funnel D....
Integrated Problem 22.90 Incorrect. In the first asymmetric synthesis of (-)-(5,5)-homaline, a symmetric alkaloid isolated in...
Integrated Problem 22.90 Incorrect. In the first asymmetric synthesis of (-)-(5,5)-homaline, a symmetric alkaloid isolated in the early 1970s, a key intermediate was compound 2 (Tetradhedron Lett. 2012, 53, 1119-1121). Provide the reagents for converting compound 1 into compound 2. Make the tertiary amine at first. 'N, Me HN Two steps .CO.Me co Me Ph Ph 1 2 Choose from the list of reagents: NH NH Hyo, Na ByCN b. HjO", NBH CN HO. NaBHCN H H HC CH d....
use the notes provided to help answer the question above. will rate well The second step...
use the notes provided to help answer the question
above. will rate well
The second step of the synthesis transformation of the chlorosulfonyl functional group into a sulfonamide) is an example of a a. Nucleophilic displacement (substitution) b Elimination C. Electrophilic aromatic substitution d. Acid hydrolysis Esterification e. THE SULFONIC ACID GROUP AND ITS DERIVATIVES Sulfonic acids are organic analogs of sulfuric acid, a very strong acid. They are highly corrosive, react vigorously with water, and can cause skin bums....
1. please check what is wrong. Thank you! Determine the product formed when each compound is treated with...
1. please check what is wrong. Thank you!
Determine the product formed when each compound is treated with Br2 and FeBr3. Drag the atom labels to their appropriate positions. CN Atom labels H H Br Br2 A. FeBr Br H OH OH Br Br. Br2 FeBr3 H H Br Br H Br2 FeBr H1 H Reset T Rank the compounds in each group in order of decreasing reactivity in electrophilic aromatic substitution. CI Decreasing reactivity Rank the compounds in each...
What is the correct name for the following compound? d) 5-oxo-3-octenoic acid What is the defining...
What is the correct name for the following compound? d) 5-oxo-3-octenoic acid What is the defining functional group of a carboxylic acid? a) an-H attached to a carbonyl group b) an-H attached to a carbon-carbon triple bond c) an-OH attached to a carbonyl group d) an -OH group attached to a O-C double bond e) an-OH group attached to an aromatic ring To convert a carboxylic acid to an aldehyde a) convert the acid to an acid chloride, then use...
CHEM 242L Exp. 4 Report/ Synthesis of Oil of Wintergreen Name Score: 20 1) Assess the effectivene...
please answer all these questions, thank you.
CHEM 242L Exp. 4 Report/ Synthesis of Oil of Wintergreen Name Score: 20 1) Assess the effectiveness of the experiment and your technique by A) reporting the yield of each step in grams and percent as well as the overall percent yield (What is "overall percent yield?). SHOW ALL CALCULATIONS! B) Give a complete analysis of the identity and purity of your final product and any isolated intermediates 2 What was the purpose...
Please Note: In cases when an instruction is given for a certain number of C atoms in your reagents that you may use, (e.g., any reagents of 3 or fewer C's), they are meant only for those reagents whose C atoms are passed to the target molecules. Also, a 20's reagent would mean two consecutive C's. For example, CH3CO2CH2CH3 would be regarded as a 2C's reagent. 3. In Corey's synthesis of PGF2, a key step is the stereoselective epoxidation of...
Question 3 (continued) (6) The drug phenaglycodol can be synthesized via a 3-step synthesis shown in Scheme 1 below. Study the synthesis and answer the following questions. HO OEt NaCNag) H2O* in EtOH A Step 1 Step 2 CI CI Compound 3 2 mol B Step 3 followed by H30* HO OH CI phenaglycodol Scheme 1 (1) Identify the electrophile and nucleophile present in Step 1 (2 marks) (1) Draw the structure of Compound A (2 marks) (111) Identify reagent...
help?
3. (6 points) The synthesis of cosalane, a new anti-HIV agent, has the following step: COOH COOH COOH HO ÇOOH сон H2SO4 HO HO OH CI 2 equiv 1 equiv Final Product Intermediate X (a) Draw an arrow-pushing mechanism for the formation of intermediate X. Show clearly how chemists rationalize the regioselectivity actually observed in the reaction. Resonance structures may help your argument. (b) Intermediate X is rapidly transformed under the reaction conditions to the final product. What is...
10. Select the compound that can not be made using the malonic ester synthesis: O O OH MeO Оме OH Ph OH A. B. Ph C. D. 11. In general both the malonic ester and acetoacetate synthesis require the addition of dilute acid in order to generate the final product. Why? A. the alkoxy cation needs to be eliminated C. the ionized cation partitions to the aqueous layer B. the stabilized enolate adds a proton in the separatory funnel D....
Integrated Problem 22.90 Incorrect. In the first asymmetric synthesis of (-)-(5,5)-homaline, a symmetric alkaloid isolated in the early 1970s, a key intermediate was compound 2 (Tetradhedron Lett. 2012, 53, 1119-1121). Provide the reagents for converting compound 1 into compound 2. Make the tertiary amine at first. 'N, Me HN Two steps .CO.Me co Me Ph Ph 1 2 Choose from the list of reagents: NH NH Hyo, Na ByCN b. HjO", NBH CN HO. NaBHCN H H HC CH d....
use the notes provided to help answer the question
above. will rate well
The second step of the synthesis transformation of the chlorosulfonyl functional group into a sulfonamide) is an example of a a. Nucleophilic displacement (substitution) b Elimination C. Electrophilic aromatic substitution d. Acid hydrolysis Esterification e. THE SULFONIC ACID GROUP AND ITS DERIVATIVES Sulfonic acids are organic analogs of sulfuric acid, a very strong acid. They are highly corrosive, react vigorously with water, and can cause skin bums....
1. please check what is wrong. Thank you!
Determine the product formed when each compound is treated with Br2 and FeBr3. Drag the atom labels to their appropriate positions. CN Atom labels H H Br Br2 A. FeBr Br H OH OH Br Br. Br2 FeBr3 H H Br Br H Br2 FeBr H1 H Reset T Rank the compounds in each group in order of decreasing reactivity in electrophilic aromatic substitution. CI Decreasing reactivity Rank the compounds in each...
What is the correct name for the following compound? d) 5-oxo-3-octenoic acid What is the defining functional group of a carboxylic acid? a) an-H attached to a carbonyl group b) an-H attached to a carbon-carbon triple bond c) an-OH attached to a carbonyl group d) an -OH group attached to a O-C double bond e) an-OH group attached to an aromatic ring To convert a carboxylic acid to an aldehyde a) convert the acid to an acid chloride, then use...
please answer all these questions, thank you.
CHEM 242L Exp. 4 Report/ Synthesis of Oil of Wintergreen Name Score: 20 1) Assess the effectiveness of the experiment and your technique by A) reporting the yield of each step in grams and percent as well as the overall percent yield (What is "overall percent yield?). SHOW ALL CALCULATIONS! B) Give a complete analysis of the identity and purity of your final product and any isolated intermediates 2 What was the purpose...
Most questions answered within 3 hours.
-
What is the relationship between a variables value and their
probabilities as it is summarized by...
asked 6 minutes ago -
Balance Sheet
DR
CR
Cash
10000
AR
7000
Supplies
500
Equipment
5,000
Accum depreciation
...
asked 3 minutes ago -
Country
Continent
GDP (millions of US$)
Afghanistan
Asia
 
asked 6 minutes ago -
1) Use the Euclidean algorithm (write in pseudocode) to find the
greatest common divisor of 8...
asked 29 minutes ago -
Based upon the corporate proposal for this week, research three
different data storage options for your...
asked 31 minutes ago -
The equilibrium constant, Kp , for the following reaction is
1.04×10-2 at 548 K. NH4Cl(s) NH3(g)...
asked 50 minutes ago -
During a recent budgeting discussion, the CFO at "NW Accounting
Services" proposed eliminating the marketing research...
asked 49 minutes ago -
Block B has a mass of 3.80kg and is moving to the left at a
speed...
asked 53 minutes ago -
If n distinct objects are distributed randomly into
n distinct boxes, what is the probability that:...
asked 54 minutes ago -
a) The frequency of light coming out from a laser source is 297
MHz. What is...
asked 1 hour ago -
LABORATORY EXERCISES:
Using nested for loops, write a java program to print the
pattern as shown...
asked 1 hour ago -
Assume that the correlation coefficient between achievement test
scores (X) and grade point averages (Y) among...
asked 1 hour ago