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3. Draw the chemical mechanism (with electron-pushing arrows) for the first step of RNA splicing (as catalyzed by the splicosome). Be sure to explicitly show the attacking nucleophile, the phosphate at the intron-exon junction, the intron branch point and the leaving group in the reaction.

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he-mRNA Exen t selicaing SH G 1 A 5 m-RNA

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