Question

6.) (2 pts) Caffeine is my very favorite biomolecule. Good sources of caffeine include coffee, tea, chocolate and colas. Caffeine is converted into a derivative of uric acid and excreted. Which enzyme would you expect to be involved in this transformation? CH, CH нс HC Caffeine 7.) (2 pts) Why should individuals who suffer from gout refrain from drinking coffee or tea?

Answer 1

6)

Caffeine is metabolized to 1,3,7-trimethyl Uric acid.

This process is oxidation , thus oxidase/dehydrogenase enzymes are involved,( caffeine dehydrogenase , like quinone-dependent caffeine dehydrogenase ).

( The enzymes that metabolize caffeine into 1,3,7-trimethyluric acid in humans include CYP1A2, CYP2E1, CYP2C8, CYP2C9, and CYP3A4. )

7)

Gout is caused by hyperuricemia, when too much uric acid builds up in the body. If persons with this these disease consume coffee or drinks/substances which contains Caffeine, the risk Gout will increase as Caffeine is metabolized to Uric acid and its analogues.