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Q5 EGF pathway 23 Points A EGF EGFR GRB2 SOS KRAS Active RAS KRAS GOP GDP GTP RAF РІЗК MEK АКТ) ERK Growth and Suppression Proliferation of Apoptosis Shown is the EGF signaling pathway. This is a pathway that normally promotes growth during development, and inhibits apoptosis (or programmed cell death). This pathway is also involved in cancer. Epidermal growth factor (EGF) binds to its receptor (EGFR). This binding activates the protein KRAS, which then activates an intracellular signaling pathway that promotes growth and proliferation.

Answer 1

5.1 EGF promotes the development of neurons. Differentiation of neural crest cells is promoted by epidermal growth factor into neurons.

5.2 Growth of colon cancer does not result from mutation, it is caused by amplification of EGFR that causes a rapid growth and highly aggressive tumors are developed.

5.3 Monoclonal antibodies having a higher degree of affinity for EGFR's extracellular domain are effective treating cancer. EGFR inhibiting drugs such as tyrosine kinase inhibitors interfere with tyrosine kinase domain.

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