Question

Draw structural formulas for the two compounds you could use to prepare the amine shown by reductive amination. NH, OH • You do not have to consider stereochemistry • Do not include the reducing agent in your answer. • If there is more than one combination, draw only one. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. Separate multiple reactants using the + sign from the drop-down menu.

Answer 1

1. As we know that the reductive amination reaction takes place between an amine and a ketone to form imine which forms a new amine which N-C bond. Through the retroanalysis, we can find the two compounds involved in the synthesis of the given compound. Removal NH2 NH Addition of H2O of H2 NH3 O OH OH OH New amine Imine Ketone + amine Answer: ОН NH3 + 2. Similarly, here the retroanalysis is as follows: Addition of H20 Removal of H2 H N NH2 N o Imine New amine Answer: NH2 Let me know if you have any queries regarding this.