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Explain what type of method you would use to identify screen for the DNA variant for each of the following scenarios; a) A we
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Answer #1

a) Denaturing gradient gel electrophoresis (DGGE,based on the migration within gradient gel electrophoresis) , Temperature gradient gel electrophoresis (TGGE), The Oxford Nanopore MinION , Heteroduplex analysis can detect missense mutations.

b)Polygenic risk score (PRS, sum of all the number of risk alleles an individual carries) . EPⓖT’s also screen for polygenic diseases for PGS testing field.

c) Single-nucleotide polymorphisms, or SNPs, Sonography (the evaluation and detection of chromosomal anomalies observed in the fetus) and Karyotyping.

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