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The neurotransmitter acetylcholine is capable of eliciting many different cellular responses depending upon the target cell.
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The acetylchiline acts through the muscarinic receprors (majorly) and nicotinic receptors. The actions of ACh through muscarinic receptors are

Muscarinic re receptous (m, -m5) M 터 Gor I Ga Gay Ms I Gi M. Gi M₂ 4 CNS Smooth mosche Ene covine gland Stimunant Eye Constri

These different actions at different targets is possible for ACh by the following pathways which involve different secondar messengers that are produced in responce to the binding of ACh to the G-protein couled receptor. The ligand for G-protein coupled receptor is ACh. The pathways involved are

G-Protien Toimenic & Blo GOP • Ligand NH លា Gipuotien coupled ? GDP الاعلای replaced by Gr GTP Try Į GTP Ontuoct with Soare p

Phospholipase pathway 1 of break down phospicotidyl inositol 1,4,5-tudy inaapi munka 2 Stimolation this pathway results in of

Thus it is possible for ACh to elicit different pharmacological actions at different targets based on the type of secondary messenger released.

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