Question

CO 6 D N 3 D N W 11- IV

In the family's pedigree shown below, a horizontal pink bar indicates that an individual is affected with hypercholesterolemia (high blood cholesterol levels). A vertical blue bar indicates that an individual is affected with Hunter's syndrome (a lysosomal storage disease). Individuals I-1 and I-2 have no family history of Hunter's syndrome, but individuals I-3 and I-4 do.

What is the mode of inheritance for Hunter's syndrome? For hypercholesterolemia?

a. Autosomal dominant

b. Autosomal recessive

c. X-linked dominant

d. X-linked recessive

e.More than one of the above are possible

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Answer #1

The mode of inheritance for Hunter's syndrome is X linked recessive disease. The women carry the defective X chromosome which can cause the disease and they can pass it on to the next generation

Hypercholesterolemia is autosomal dominat condition. The parent who carries the altered genes has 50% chance to pass it on to the child or next generation.

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