Question

Although each class of extracellular receptors can respond to a wide variety of signals, certain types of responses are more frequently elicited by the different classes Mutations in the downstream signalling cascade of which type of receptors are most likely to be associated with the development and progression of cancer? Enzyme-coupled receptors protein coupled receptors lon-channel coupled receptors

Answer 1

1) In the above 1st question answer will be the

Ans- option B that is G protein couple receptor, if mutation occour in downstream signaling then calcium sensing receptor changes.for this changes its help the development and progression of cancer. It is the cell surface,G-protein couple receptor.

2) In the above 2nd question answer will be the

Ans- Option E that is it must be G protein coupled receptor. In the G protein signaling pathway there is some G-alpha type that is G-alpha i, G-alpha s, G-alpha t, G-alpha q etc. So in the G-alpha q subunit stimulate phospholypase c-beta and phospholyte c-beta hydrolysis of PIP2 produce IP3 and DAG.

IP3- it release ca2+ that can play varity of role in our body .

DAG- it activated protein kinase C.