Question

A very popular drug in the treatment of the herpes simplex virus (HSV-1) is called acyclovir. When it comes to the treatment of HIV, the virus that causes AIDS, the most popular drug of choice is AZT (Retrovir).

1. Explain why these drugs are called nucleoside analogues and which nucleotides these are analogues of? (0.5 pt.)
2. Hypothesize how each of these drugs might be affecting the DNA replication of the viruses they are meant to target. Use a drawing to aid in your answer. (1 pt.)

Answer 1

A) The nucleoside analogies contains the nucleic acid analogue , a phosphate moeity and a Sugar molecule . Addition of the nucleotide analogues result in the termination of the process of replication . It also competes with the nucleoside to participate in the process of replication. Therefore it act as a competitive inhibitor of nucleoside. It also results in the process of termination. Acyclovir is a purine analogue that is adenosine and Guanosine analogues structure . AZT or Zidovudine is used in termination of HIV replication . AZT works on the mechanism of the salvage pathway in which it is converted into monophosphate form .

B) Summary :- DNA

AZT Mechanism o Atuour of Nylovir & Azt Properties incell. In HIV-Infeited cell In HIV. Infected cell. viral -Acyclovir Huzuident kinase Acyclovik-menophosphate AZT- nowop losplante Actorize -triplosplante AZT-triphosphate Cellular thelnudine kinase. -AZT -Aly 5' further HIV DNA Synthesis further HSV DNA replications inhibited due to lack of 30H. from vinal RNA inhibited due to lack 3'0H.

replication is inhibited due to the the absence of 3'OH at the 3' end .The monophosphate form is converted into triphosphate form which binds to the the DNA in the replication process and inhibits the the further replication . The mechanisms is well explained in diagram .

Thanking you

Have a beautiful day ?

Regards

Good luck ✨

Please Hit the thumbs up ??