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2. (2.5 pts.) Shown below is the general mechanism for the interconversion of the enantiomers of...
Please write NEATLY and CLEARLY. Make arrows very obvious. 2. [2.5 pts.) Shown below is the general mechanism for the interconversion of the enantiomers of thalidomide. Draw the appropriate curved arrow pushing for each step of the mechanism. H-OH ÖH2 + H-SHz H N -0+ H-OH2 -N 0:0 H
7. (4 pts.) In Figure 3 of Section 4 “Designing the Drug Thalidomide”, two possible hydrolysis products are shown. Provide the mechanism to generate compound 4. The first step of the mechanism with the curved arrow pushing is done for you. O + H-OH2 -N: Н. 0:0:- -NH2 N- 4 -ОН о о
Please write NEATLY and CLEARLY. (7.4 pts.) In Figure 3 of Section 4 “Designing the Drug Thalidomide”, two possible hydrolysis products are shown. Provide the mechanism to generate compound 4. The first step of the mechanism with the curved arrow pushing is done for you. + H-OH2 -N: :O: H -NH2 OH 0 SA H OH 5 -NH2 Figure 3: Possible biological degradtion products of thalidomide
In Figure 3 of Section 4 “Designing the Drug Thalidomide”, two possible hydrolysis products are shown. Provide the mechanism to generate compound 4. The first step of the mechanism with the curved arrow pushing is done for you. I' + H-OH2 -N: -NH, N 4 ОН о о
Provide the mechanism to generate compound 4. The first step of the mechanism with the curved arrow pushing is done for you. -NH2 H O + H-OH2 4 -ОН 0:0:- H
Provide the mechanism to generate compound 4. The first step of the mechanism with the curved arrow pushing is done for you. -NH2 H O + H-OH2 4 -ОН 0:0:- H
Question 8 (24 pts). For EACH, give a complete curved arrow pushing mechanism, and... 1) Show ALL important resonance contributors for all intermediates. 2) Add non-bonding electrons and C-H bonds to the line-angle structures as required 3) Indicate the Lewis acid/Lewis base (LA, LB) at each step as appropriate, and whether they are also Bronsted acids/bases (LA/BA, LB,BB) :Ö-MgBr Excess PhMgBr a) Ph Ph :Ö-MgBr O-H H3O+ b) Ph Ph Ph Ph part b) is not a trick, it is...
b Write a mechanism for the step shown below, using curved arrows to show electron redistribution. Arrow-pushing Instructions =XT ö: 0: C=N; CH3CH3 CH3 :OCH2CH3 HH
Part B (2 of 2) Draw the curved arrows for Step 5 of this mechanism. Arrow-pushing Instructions no-xm НА Н 0: Step 5 CH3 CH3 نی IÓ I H3C CH3 H I- Η :0: Ι Η CH3 H3C Hgc H Η I- Part B (2 of 2) Draw the curved arrows for Step 5 of this mechanism. Arrow-pushing Instructions ООС Хm HzC CH3 Н- CH3 HẠC н—с CHỊ CH3 Step 5 НАС H3C :0 —н. :0-н
Part B (2 of 2) Draw the curved arrows for Step 2 of this mechanism. Arrow-pushing Instructions naux 0-H HE H-o: :: H3C 2 C C H3C1 Step 2 0-H CH3 Step 2 CH3 H-0: H3CC с H3C c H < Check (2 of 2)