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Provide the mechanism to generate compound 4. The first step of the mechanism with the curved...
Provide the mechanism to generate compound 4. The first step of the mechanism with the curved arrow pushing is done for you. -NH2 H O + H-OH2 4 -ОН 0:0:- H
7. (4 pts.) In Figure 3 of Section 4 “Designing the Drug Thalidomide”, two possible hydrolysis products are shown. Provide the mechanism to generate compound 4. The first step of the mechanism with the curved arrow pushing is done for you. O + H-OH2 -N: Н. 0:0:- -NH2 N- 4 -ОН о о
Please write NEATLY and CLEARLY. (7.4 pts.) In Figure 3 of Section 4 “Designing the Drug Thalidomide”, two possible hydrolysis products are shown. Provide the mechanism to generate compound 4. The first step of the mechanism with the curved arrow pushing is done for you. + H-OH2 -N: :O: H -NH2 OH 0 SA H OH 5 -NH2 Figure 3: Possible biological degradtion products of thalidomide
In Figure 3 of Section 4 “Designing the Drug Thalidomide”, two possible hydrolysis products are shown. Provide the mechanism to generate compound 4. The first step of the mechanism with the curved arrow pushing is done for you. I' + H-OH2 -N: -NH, N 4 ОН о о
Provide the complete curved arrow mechanism for the rearrangement shown here. Hint: The first step makes the alcohol a better leaving group using a proton source. H-CI OY он H-0
Draw curved arrows to show the movement of electrons in this step of the mechanism. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions nga XT :00 Ph H3c-tö- PhẳNH H₃C N" H₃co CHỊ next Ph-NH2 H3Co PhNH - Ph—ŃHz CHỊ H3c-töl Ph–NH CH3 nggam '0 ' with the H₃C/ Ph Нsc H3COOH | Pháo: CH
draw curved arrows to show the movement of electrons in this step of the reaction mechanism HCI H2O NH,CI -CEN ОН Acid catalyzed hydrolysis of a nitrile to give a carboxylic acid occurs by initial protonation of the nitrogen atom, fo Draw curved arrows to show the movement of electrons in this step of the reaction mechanism Arrow-pushing Instructions O: x H -CI: -NH₂ SLIDE ty Another Mansion 1 terrattuttomat
2. (2.5 pts.) Shown below is the general mechanism for the interconversion of the enantiomers of thalidomide. Draw the appropriate curved arrow pushing for each step of the mechanism. H H 0 + H-OH2 + ÖH2 O :O: H Do H IM + OH2 O + H-OH2 O :O H Do O:O: H H H O + H-OH2 N O:O: H
First box is to add in curved arrows that illustrate the first step of this mechanism. Second box is Draw the two intermediates that form and show curved arrows depicting the next step. Third is Draw the intermediate and the small molecule with which it will react. Show curved arrows depicting the next step. Fourth box is Draw the intermediate and the small molecule with which it will react. Show curved arrows depicting the next step. 05 Question (1 point)...
Provide a curved-arrow mechanism for the first step of the reduction of vanillin with borohydride in methanol. Show and explain the role of the protic solvent in the reaction.