Question

QUESTION 35 Eukaryotic ribosomes cannot translate polycistronic mRNAs, Parvovirus utilizes which of the following strategies to solve the "polycstrone RNA problem: A parvovirus is not polycstronic B. alternative splicing OC segmented genome OD. protease cleavage of a polyprotein O E multiple IRES QUESTION 36 During hepatitis B virus maturation, which of the following happens to the vesicles studded with spike proteins if they do not encounter a capsid: A they re-enter the nucleus B. they are inserted into the plasma membrane of the cell c. they bud out from the cell as non-infectious particles D. they are "recycled by the cell E. they contribute to the liver cancer that is associated with hepatitis B virus

Answer 1

Q 35. Eukaryotic ribosomes cannot translate polycistronic mRNA. Parvovirus produces a polycistronic mRNA but is translated by it's host ribosomes. The mRNA produced contains multiple overlapping Open Reading Frames (ORFs); the mRNA undergoes alternate splicing to allow translation from the different ORFs.

Q 36. The vesicles containing spike proteins but no capsid (which contains the viral genome) bud out of cell as incomplete particles. These incomplete viral particles are non-infectious as they don't have the genome.