Question

QUESTIONS Using the list, propose the forward synthesis of the retrosynthesis shown below any number of steps can be used, so long as they get to the desired product in as high a regioselectivity as possible). Please report your answer by typing the letterssymbols sequentialy НО. ana OH A. CUCI, 0 °C B. CuBr, 0 °C C. Cu20, Cu(NO3)2, H20, 0 °C D. EuCN, 0 °C E. SO3, H2SO4, 100 °C F. Cl2, FeCl3, THF, 65 °C G. Bre, FeBr3, THF, 65 °C H. ACCI, AICI3, THF, 65 °C I. H2, Pd/C, EtOH, 25 °C J. KMnO4, H20, 100 °C K. CrO2, H2SO4, Acetone, 0 °C L. NaOH, H2O, 100 °C M. H2O, Dilute H2SO4. 100°C N. HNO3, H2SO4, 60 °C O. NaNO2, H2S04.0°C P. mCPBA, DCM, 25 °C Q, KCN, MeCN, 50 °C R. H2NBn, 150 °C S. SOCI2, 75 °C T. LiAlH4, THF, 0 °C U. PBr3, 50 °C V. NaBH4, EtOH, 25 °C W. NaOH, EtOH, 100 °C X. H2SO4, H20, 100°C Y. HBr, EtOH, 50 °C Z. NaNO2, H2SO4, 0 °C !. H2NBn, Et3N, DCM, 40 °C #. Mg, cat. 12, Et 0, 35 °C $. EtOH, 25 °C %. NaOH, EtOH, 78 °C ^. CO2, Et20, 25 °C &. TSCI, Et3N, DCM, 25 °C * KOtBu, HotBu, 50 °C

Answer 1

The complete reaction scheme is shown ملی 17 H2O, HO dil H₂SO4, A OH below Р M-PBA, Dem, 2500 step. I step-I The first step is called Bayer-villiger oxidation to form a lactone B. Hydrolysis of lactone B in presence of H₂o, catalytic H2SO4 at loo°c will give desired product with high yeild. Therefore, answer is PM