Question

Using the list, propose the forward synthesis of the retrosynthesis shown below (and number of steps can be used, so long as they get to the desired product in as high a regioselectivity as possible). Please report your answer by typing the letters/symbols sequentially. A. Ph3PMeBr, KotBu, PhMe, 25 °C B. CuBr, 0 °C C. Cu20, Cu(NO3)2, H20, 0 °C D. CuCN, 0 °C E. SO3, H2SO4, 100 °C F. Cl2, FeCl3, THF, 65 °C G. Br2, FeBr3, THF, 65 °C H. ACCI, AICI3, THF, 65 °C I. H2, Pd/C, EtOH, 25 °C J. KMnO4, H20, 100 °C K. CrO3, H2SO4, Acetone, 0 °C TTT Arial 3 (12p T.E L. NaOH, H2O, 160 °C M. H20, Dilute H2SO4, 100°C N. HNO3, H2SO4, 60 °C O. K2CO3, Mel, MeCN, 82 °C P. mCPBA, DCM, 25 °C Q. KCN, MeCN, 50 °C R. H2NBn, 150 °C S. SOCI2, 75 °C T. LIAIH4, THF, 0 °C U. PBr3, 50 °C V. NaBH4, EtOH, 25 °C W. NaOH, MeOH, 100 °C X. H2SO4, H20, 100°C Y. HBr, EtOH, 50 °C Z. NaNO2, H2SO4,0 °C !. H2NBn, EtzN, DCM, 40 °C #. Mg, cat. 12, Et20, 35 °C $. MeOH, 25 °C %. NaOH, MeOH, 65 °C ^. CO2, Et20, 25 °C &. HCI, MeOH, 65 °C * KOtBu, HotBu, 50 °C

Answer 1

Answer :

Forward synthesis of Reterosynthesis given is shown in the image attached

Basically to convert benzene to styrene.

Reagents used are : HVX

(1) First step is Friedal craft acylation reaction to form Acetophenone using Reagent H .

(2) Second step is Reduction Reaction of ketone to alcohol using reducing agent (V) NaBH4 / MeOH .

(3) Dehydration reaction of alcohol to remove H2O using dehydrating agent H2SO4 at boiling temperature of H2O (100°C) .

So sequence of reagent : HVX .

This is just one set of Reagent , there is other set of Reagent also possible for this conversion reaction.

Answer → Forst step is Friedal craft Acylation reaction CH). Accl, A193 Chf Cutz 65°C Acllo CHa coce acetophenone second step is reduction of aceptophenome using ♡ NaBly , ELOH OH ECH3 C-CH3 H Therd step is OH dehydration of alcohol. wing (x) (CH3 Hy sou H₂O 11 C=CH 100°c - to Required broduct Reagents used oor HVX