Question

The following reaction will not proceed as written. Clearly explain why this reaction will not occur.

The following reaction will not proceed as written. Clearly explain why this reaction will not occur. 1. LDA ix 2. Br

Answer 1

Li-N lithium diisopropylamide (LDA) strong base Br nucleophilic carbon strong nucleophile This attack is a SN2 reaction However, as the C-Br bond is very high (as this is a tertiary carbon), thus the SN2 reaction cannot take place. Thus, we didnot observe any product formation H-N