Question

Copy 2 of In tigers, 24 units of enzyme activity are needed for the wild-type (striped) phenotype. Less than 24 units of activity results in a solid colored tiger. Al is the WT allele and produces an enzyme with 16 activity units A2 is the mutant allele and produces an enzyme with 10 activity units Which allele is dominant, and what is the phenotype of a heterozygous tiger? Explain your answer and state whether this is an example of haplosu fficiency or haploinsufficiency (referring to the wild-type allele). TT T Arial ✓ 3 (12pt) T. E- Qix

Answer 1

The genotype of the heterozygous tiger is Aa

Since A allele contributes to 16 activity units and a allele contributes to 10 activity units.

Therefore Aa will contribute 26 activity units.

Hence the tiger will be wild type (Stripped).

Here none of the alleles is dominant, as each allele is contributing its own activity.

This is the case of haploinsufficiency because the wild type allele is not sufficient to produce the wild type phenotype and requires the contribution of both the alleles (WT as well as mutant).

Thank you