Question

Question 8 1 pts (Select all Recombination signal sequences (RSS) that apply.) contain spacer sequences that are either 7 or 9 base pairs in length contain conserved DNA sequences that are recognized by enzymes that facilitate the cutting and rejoining of gene segments ensure that the gene segments undergoing somatic recombination are joined in the correct order are located between the exons encoding the leader peptide and the V-region segments

Answer 1

1. Contain conserved DNA sequences that are recognized by enzymes that facilitate the cutting and rejoining of the gene segments.

2. Ensure that the gene segments undergoing somatic recombination are joined in the correct order.

The recombination signal sequences (RSSs) consists of a conserved heptamer and nonamer motifs separated by a less well-conserved spacer of either 12 or 23 base pair (bp) in length. Recombination is possible between signal sequences with unequal spacers results in productive coding genes. This phenomenon is known as the “12/23 rule.” These signals are present immediately downstream of every V-genes, flanks D_H and J segments and upstream of every C gene. The class switching involves S-regions.