Question

Using retrosynthetic analysis, provide a synthesis for the following molecule. Place the required reagents next to the arrows and the necessary

HH iPr: + MeOCCO Me 1. 8. 2. 9. 3. 7. 4. 5. Me NH2 6. Me MeOCCO Me

Answer 1

come, come SH Ques Solve Giver; starting madenial Retrosynthesis CH, i-pr. Cleavage of Noc bond and Reverse of x- carbonyl decarboxylation th fn -NH₂ BY H₃C he deprotection of NHh mec Toome megc Corne Coome H Protection cleavage of NH₂ of NH A Bond mezc 'Cl (by Swa) meqca To, me coame JU + CI Come megc Forward synthesis (startimy malenica) For Reagent t; acid-base reaction teule place for 2-deptotoncation, followed by Reagent 2 Scuz reaction followed by Hydrolysis. again; Fox Reagent 4 again; como outonation followed by SPZ reaction. and hydrolysis. For Reagent 7; Poutection of Nitrogen Camine) by Benzyl chloride.; For Reagent 8; decarboxylation Reagent 9 deprotection of N-Benzyl. i-Po=) isopropy |(1) CHome/(thom meqa . Come (2) Loo 79) Helpd;c =) (depootection of N-Benzy)) meer (A) HLJ, Ho, Heat (3) tho (oame Bn (1) CHome/Cholt Brk Nth (21) -Cl IN Yozme meoc (CH323 N Yo me megc (37) to CS Scanned with CamScanner