23.8 Propose the two ester starting materials for the crossed Claisen product shown below. a time...
8. Give products or required starting materials for these crossed-Claisen condensations that use two different esters. Note that the first ester is added to the base to form an enolate. (If the base were added to the ester, enolates would form and react with the ester present in the flask). Give the enolate for the first reaction. 1) O 2) OK iPro ОMe Meo t-butoxide THF 1) 2) N LÝ OMe Eto Meo LDA 1) 2) Meo Оме Eto LDA...
22. The mixed Claisen reaction shown provides product in only a trace amount. The starting materials are obtained upon isolation. Why? co Me CO2Me NaoMe MeOH CO2Me / dil. HCI Ph A. pka of the propyl ester is too high B. there is only one a-proton C. the benzoate ester is resonance stabilized D. pka of the propyl ester is too low
22. The mixed Claisen reaction shown provides product in only a trace amount. The starting materials are obtained upon isolation. Why? CO Me .CO Me NaoMe меон .CO.Me dil. HCI Ph A. pka of the propyl ester is too high C. the benzoate ester is resonance stabilized B. there is only one ce-proton D. pka of the propyl ester is too low +
22. The mixed Claisen reaction shown provides product in only a trace amount. The starting materials are obtained upon isolation. Why? CO Me CO Me NaOme MeOH CO Me / dil. HCI Ph Y come A. pka of the propyl ester is too high B. there is only one a-proton C. the benzoate ester is resonance stabilized D. pka of the propyl ester is too low 23. Select the product for the reaction shown: NaOH Ph H2O, THE 5 °C...
1) The following mixed Claisen reaction produces only a trace amount of product. The starting materials are obtained upon isolation. Why? CO2Me CO2Me NaOME MeOH CO Me / dil. HCI Ph A. pka of the propyl ester is too high B. there is only one a-proton C. the benzoate ester is resonance stabilized D. pka of the propyl ester is too low 2) Which of the following compounds will be formed from the reaction below: NaOH Ph H2O, THE 5...
22. The mixed Claisen reaction shown provides product in only a trace amount. The starting materials are obtained upon isolation. Why? .CO2Me NaO Me CO2Me MeOH CO2Me / dil. HCI Ph you + A. pka of the propyl ester is too high B. there is only one a-proton C. the benzoate ester is resonance stabilized D. pka of the propyl ester is too low
16. Give the major organic product of each Claisen reaction. a. NOF: A WHO it heat b. H.H.O. ETO a. NaoMe b. H. H,0,hea MCO- a. NaOE. a. NaOme. O Mco CCH) OMe b. H.H.O, heat 17. Propose starting materials needed to synthesize each molecule through a Claisen reaction. a. F10 1 1 1 d. EOYOE 1 Ph YYY = 1
The mixed Claisen reaction shown provides product in only a trace amount. The starting material obtained upon isolation.why?? .CO. Me NaOM 22. The mixed Claisen reaction shown provides product in only a trace amount. The starting materials are obtained upon isolation. Why? CO,Me MeOH co Me dil. HCI A pka of the propyl ester is too high C. the benzoate ester is resonance stabilized B. there is only one ce-proton D. pka of the propyl ester is too low Ph
19. Provide the product for the alkylation transformation: O LDA / EtBr product D. C. A. B. 22. The mixed Claisen reaction shown provides product in only a trace amount. The starting materials are obtained upon isolation. Why? CO2Me NaoMe CO2Me MeOH CO2Me / dil. HCI Ph + A. pka of the propyl ester is too high B. there is only one a-proton C. the benzoate ester is resonance stabilized D. pka of the propyl ester is too low
10. Propose starting materials needed to synthesize each molecule through an aldol reaction. a. b. c. d. H f. 11. Give the curved arrow mechanism for each Claisen reaction. a. NaOEt a. b. mild H EtO EtO 1 11 continued a. NaOMe MeO b. b. mild H МеO a. NaOEt с. b. mild H