10. Propose starting materials needed to synthesize each molecule through an aldol reaction. a. b. c. d. H f. 11....
Give the major organic product of each reaction. 8. a. LDA н b. H c. mild H NaOH, H,O н a, LDA b. f. н NaOH, H,O, heat c. mild H NaOH, H,O O NaOH, H,O H CYD a. LDA b. d. h. NaOH, H,O, heat c. mild H*, heat 9. Give the major organic product of each intramolecular Aldol reaction. NaOH, H,O a. heat H NaOH, H2O b. heat NaOH, H,O NaOH, H20 d. heat 10. Propose starting materials...
11. Give the curved arrow mechanism for each Claisen reaction. a. NaOEt a. b. mild H EtO EtO HEEO EEO Et Eto EtO Eto Etdo 169 11 continued a. NaOMe МеO' b. b. mild H МеO'
17. Propose starting materials needed to synthesize each molecule through a Claisen reaction. a. Eto = = OME OMe = = Ph = =
10. Propose starting materials needed to synthesize each molecule through an aldol reaction. من . . ) » سالب = ، د سال دیگر = = مر
17. Propose starting materials needed to synthesize each molecule through a Claisen reaction. a. Etor = = COMe = d. EO Y OEt f Ph TY = =
12. Explain why a Claisen reaction occurs with ester E, but not with ester F. Eto EIO E F 13. Give the major organic product of each Claisen reaction. In some cases, no reaction is expected. a. NaOEt a. NaoMe OMe b. mild H Et01 b. mild H a. NaOMe a. NaOme. Meo MeO b. mild H MeO b. mild Hº 13 continued a. NaOE AOE a. NaOE, O Eto OE OE OEt c. mild H b. mild H a....
16. Give the major organic product of each Claisen reaction. a. NOF: A WHO it heat b. H.H.O. ETO a. NaoMe b. H. H,0,hea MCO- a. NaOE. a. NaOme. O Mco CCH) OMe b. H.H.O, heat 17. Propose starting materials needed to synthesize each molecule through a Claisen reaction. a. F10 1 1 1 d. EOYOE 1 Ph YYY = 1
Problem 19.36a-b Draw the starting materials needed to synthesize each of the following compounds using an aldol reaction. If only one compound is required, check the "No Reaction" box for the lower molar mass compound. Get help answering Molecular Drawing questions. X Incorrect. (a) XnPh Edit greater molar mass compound Edit x Incorrect. greater molar mass compound lower molar mass compound No reaction
6. Give the major organic product from each mixed aldol reaction. Then explain why the reaction conditions favor one product instead of generating a mixture of products. NaOH a. + Н,о "СС, NaOH b. Н.о a. LDA c. b. О H н 7. Give the curved arrow mechanism for this reaction. NaOH, H,O Н heat
Draw a structural formula for the product of the aldol reaction of the compound shown above, as well as the a.B-unsaturated aldehyde or ketone formed from dehydration of the aldol product. You do not have to consider stereochemistry. You do not have to explicitly draw H atoms. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right comer. Separate structures using the sign from the drop-down menu. . o 1. Og 2. (CH3)2...