11. Give the curved arrow mechanism for each Claisen reaction. a. NaOEt a. b. mild H...
10. Propose starting materials needed to synthesize each molecule through an aldol reaction. a. b. c. d. H f. 11. Give the curved arrow mechanism for each Claisen reaction. a. NaOEt a. b. mild H EtO EtO 1 11 continued a. NaOMe MeO b. b. mild H МеO a. NaOEt с. b. mild H
Give the major organic product of each reaction. 8. a. LDA н b. H c. mild H NaOH, H,O н a, LDA b. f. н NaOH, H,O, heat c. mild H NaOH, H,O O NaOH, H,O H CYD a. LDA b. d. h. NaOH, H,O, heat c. mild H*, heat 9. Give the major organic product of each intramolecular Aldol reaction. NaOH, H,O a. heat H NaOH, H2O b. heat NaOH, H,O NaOH, H20 d. heat 10. Propose starting materials...
12. Explain why a Claisen reaction occurs with ester E, but not with ester F. Eto EIO E F 13. Give the major organic product of each Claisen reaction. In some cases, no reaction is expected. a. NaOEt a. NaoMe OMe b. mild H Et01 b. mild H a. NaOMe a. NaOme. Meo MeO b. mild H MeO b. mild Hº 13 continued a. NaOE AOE a. NaOE, O Eto OE OE OEt c. mild H b. mild H a....
14. Reaction of the following diester with NaOEt followed by mild Ht makes product G, not product H. Explain why there is a preference for forming product Gover H. a. NaOEt OEt not "OEib mild H* 15. Give the curved arrow mechanism for the decarboxylation and keto-enol tautomerism steps in this reaction (from 3 to K). مه-حل-ا مل a. NaOEt b. H, H30, heat
9. Give the curved arrow mechanism for each reaction. H2SO4 b. H,o OH c. H20 H2SO d. OH H2o 10. For the following reaction, H,so, H,O он a. Give the curved arrow mechanism for the reaction, showing formation of both products b. Identify the major product and explain why it is favored. c. Draw the energy diagram for the formation of the major product. 11. Give the major organic product for the following reactions. If a racemic mixture is expected,...
16. Give the major organic product of each Claisen reaction. a. NOF: A WHO it heat b. H.H.O. ETO a. NaoMe b. H. H,0,hea MCO- a. NaOE. a. NaOme. O Mco CCH) OMe b. H.H.O, heat 17. Propose starting materials needed to synthesize each molecule through a Claisen reaction. a. F10 1 1 1 d. EOYOE 1 Ph YYY = 1
29. Give the curved arrow mechanism for each reaction. DOH H2SO4, H,O heat F H2SO4, H2O . х арин OH H SOHO heal 30. For the following reaction, OH H,SO,H,O heat a. Draw the curved arrow mechanism. b. Use the mechanism to explain why acid is a catalyst in the dehydration reaction. C. Draw the energy diagram.
33. Give the curved arrow mechanism for each reaction. / ОН H2SO4, H,0 heat H SO, H,0 heat
18. Give the curved arrow mechanism for each reaction. KOH, H2O KOH,H,O O NaOH,H,O 0028
1. Provide a reasonable curved arrow mechanism for the following transformation. (20 points) 1) NaOEt EO VOEt Et EtOH Ph Ph 3)HCI, H20 DMSO, Heat