Question

C22T03Q6035 Give the major product(s) of the following reaction. O NH3 ? heat OH I-Z N-H NH2 H + NI

Answer 1

Reaction 1 and 4

Carboxylic acid reacts with ammonia by nucleophilic addition mechanism. In first step ammonia add to carbonyl carbon using its lone pair of electron, and ammonium carboxylate is formed. When ammonium carboxylate is heated it lose water molecule and amide is final product of the reaction.

Reaction 2

This reaction is an acid base reaction, ammonium salt give proton by reacting with sodium hydroxe and convert to triethylamine and water.

Reaction 3

Carboxylic acid reacts with primary amine by nucleophilic addition mechanism. In first step methyl amine add to carbonyl carbon using its lone pair of electron, in second step lose of water molecule final product N-methylformamide is formed.

0 Carbonylic acid react with ammonia to give amide, the reaction given below rhon NH3. ó Nhu Heat butanoic acid ہ Å NH+H2O (Butanamide) Final product 3 NaOH Ń + H₂O + Nat Amoni Ammonium ion reacts with NaOH, to give tertiary amine and water molecule. Major products are and H₂O -- 3 Formic acid reacts with methy amine to give N-methegl formamide. i + CHE NH24 H NH- CH3 +H2O M •OH N-methyl formamide +H2O "NH/ Hi major product

9 carboxylic acid reacts with ammonia to give amide, the reaction given below- o ♡ NH3 & NH2 + H2O OH heat propanoic aud Propang mide