Many newer drugs are proteins. Discuss THREE factors that affect the stability of proteins and the...
Many newer drugs are proteins. Discuss THREE factors that affect the stability of proteins and the approaches in the formulation and handling of proteins used to minimise stability problems
Homework Answers
Three factors that affect stability of proteins are:
1. Hydrophobic interactions
2. Hydrogen bonds
3. Temprature
4. Metals
APPROACHES IN THE FORMULATION AND HANDLING OF PROTEINS
- Proteins are important in drug therapy. Protein affect drug efficacy. Ability to survive long term storage.
- Aggregation and misfolding is an issue of long term storage
- Denaturation
- Oxidation
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Many newer drugs are proteins. Discuss THREE
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